Activity

Classical Theory courses in the U.S. present a history of our discipline grounded in the works of Durkheim, Marx, and Weber, defining “classic” by space and time, giving pre-World War II Europe credit for creating the foundation of contemporary sociology. While past critiques of this canon have argued for expanding the geographic bounds outside of Europe, these efforts still ground the origins of social theory in a time period of racial exclusion and segregation. We argue for a reckoning with the racial origins of the discipline in the United States in anti-Blackness and the legacies of racial exclusions. We must grapple with the histories of exclusion and segregation that continue to impact the discipline’s present and futures. In this paper, we argue that the teaching of sociology’s history should be through the “Foundations of Social Theory,” a broad approach to teaching that rejects the ideas of both “classics” and a “canon.” This approach roots theory in our history through core issues of study (e.g., the origins and consequences of capitalism) and directly addresses past racial and gendered exclusions by centering BIPOC intellectual contributions across time. By lifting the time and space restrictions, we open the doors to including voices omitted and repressed due to the exclusion of BIPOC people, especially Black women, from higher education in the U.S. This approach acknowledges the diverse histories and voices in our classrooms and profession, and highlights the relevance of social theory for our future.The study applies and expands the routine activity theory to examine the dynamics of online harassment and violence against women on Twitter in India. We collected 931,363 public tweets (original posts and replies) over a period of 1 month that mentioned at least one of 101 influential women in India. By undertaking both manual and automated text analysis of “hateful” tweets, we identified three broad types of violence experienced by women of influence on Twitter dismissive insults, ethnoreligious slurs, and gendered sexual harassment. The analysis also revealed different types of individually motivated offenders “news junkies,” “Bollywood fanatics,” and “lone-wolves”, who do not characteristically engage in direct targeted attacks against a single person. Finally, we question the effectiveness of Twitter’s form of “guardianship” against online violence against women, as we found that a year after our initial data collection in 2017, only 22% of hostile posts with explicit forms of harassment have been deleted. We conclude that in the social media age, online and offline public spheres overlap and intertwine, requiring improved regulatory approaches, policies, and moderation tools of “capable” guardianship that empower women to actively participate in public life.The Cattaneo telegraph equation for temperature with moving time-harmonic source is studied on the line and the half-line domain. The Laplace and Fourier transforms are used. Expressions which show the wave fronts and elucidate the Doppler effect are obtained. Thapsigargin price Several particular cases of the considered problem including the heat conduction equation and the wave equation are investigated. The quasi-steady-state solutions are also examined for the case of non-moving time-harmonic source and time-harmonic boundary condition for temperature.Small populations are often exposed to high inbreeding and mutational load that can increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is now restricted to small and isolated populations on Sumatra and Borneo, and most likely extinct on the Malay Peninsula. Here, we analyse 5 historical and 16 modern genomes from these populations to investigate the genomic consequences of the recent decline, such as increased inbreeding and mutational load. We find that the Malay Peninsula population experienced increased inbreeding shortly before extirpation, which possibly was accompanied by purging. The populations on Sumatra and Borneo instead show low inbreeding, but high mutational load. The currently small population sizes may thus in the near future lead to inbreeding depression. Moreover, we find little evidence for differences in local adaptation among populations, suggesting that future inbreeding depression could potentially be mitigated by assisted gene flow among populations.Stimulated and spontaneous interactions of electron wavepackets with optical near fields were explored with complementary techniques. In striking agreement with theory, scientists have demonstrated the dependence of spontaneous and stimulated quantum mechanical processes on the spatial distribution of optical modes.The loss-of-function mutations in the ALPL result in hypophosphatasia (HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain, chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Here, we show that ALPL deficiency caused a reduction in intracellular Ca2+ influx, resulting in an osteoporotic phenotype due to downregulated osteogenic differentiation and upregulated adipogenic differentiation in both human and mouse bone marrow mesenchymal stem cells (BMSCs). Increasing the intracellular level of calcium in BMSCs by ionomycin treatment rescued the osteoporotic phenotype in alpl+/- mice and BMSC-specific (Prrx1-alpl-/-) conditional alpl knockout mice. Mechanistically, ALPL was found to be required for the maintenance of intracellular Ca2+ influx, which it achieves by regulating L-type Ca2+ channel trafficking via binding to the α2δ subunits to regulate the internalization of the L-type Ca2+ channel. Decreased Ca2+ flux inactivates the Akt/GSK3β/β-catenin signaling pathway, which regulates lineage differentiation of BMSCs. This study identifies a previously unknown role of the ectoenzyme ALPL in the maintenance of calcium channel trafficking to regulate stem cell lineage differentiation and bone homeostasis. Accelerating Ca2+ flux through L-type Ca2+ channels by ionomycin treatment may be a promising therapeutic approach for adult patients with HPP.