Wong Knudsen

Roxithromycin (ROX) is a widely used macrolide antibiotic and its environmental fate and ecotoxicity have attracted considerable attention. In this study, the phototransformation kinetics and products of ROX under the irradiation of simulated sunlight were investigated. The ecotoxicity of ROX before and after phototransformation were also examined…[Read more]

Five Exodeconus species were phytochemically analyzed. From the aerial parts of E. pusillus, the 7α,27-dihydroxy-1-oxo-22R-witha-2,5,24-trienolide and three other previously unreported normal-type withanolides were isolated. All the studied species had normal type and/or ring-D aromatic withanolides, and some had already been isolated from other…[Read more]

The GPR17 receptor, expressed on oligodendroglial precursors (OPCs, the myelin producing cells), has emerged as an attractive target for a pro-myelinating strategy in multiple sclerosis (MS). However, the proof-of-concept that selective GPR17 ligands actually exert protective activity in vivo is still missing. Here, we exploited an iterative drug…[Read more]